SLIM TLC® Supercharged! is a more customized, hybrid program that combines the lowest effective and tolerated doses of both phentermine and Wegovy® (semaglutide), a GLP-1 RA (glucagon-like peptide-1 receptor agonist), or Zepbound® (tirzepatide), a GLP-1/GIP (glucose-dependent insulinotropic peptide) RA to provide you with the most effective program overall, while minimizing the potential negative side effects of both (the most concerning of which, for most people, are associated with semaglutide – primarily nausea and muscle loss). A list of negative side effects for both medicine types are summarized below.